CAR T CD1a Immunotherapy for coT-ALL

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T-ALL comprises 10–15% of all acute leukemias diagnosed in children and 20–25% in adults, with a median diagnostic age of 9 years. Survival of patients with T-ALL treated with intensive chemotherapy remains less than 70%, and relapsed/refractory (r/r) T-ALL has a particularly poor outcome of 6% to 20% in 5 to 10 years. OC-1 is a CART CD1a Immunotherapy developed as a treatment for refractory relapsed patients with cortical T-ALL, a T-ALL subgroup without many options to date. OC-1 received Orphan Drug Designation (ODD) from the EMA in 2021.


CAR T CD1a/OC-1.2 Immunotherapy for T-ALL

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OC-1 covers the co-T-ALL subtype which represents 30-40% of all T-ALL. In this sense, OneChain has identified OC-1.2 as a new target for T-ALL patients, and humanized OC-1.2-directed CARs have been developed, encouraging the development of a dual CD1a/OC-1.2 CAR (OC-1d). Dual targeting of these T-ALL-specific antigens will: i) widen the number of R/R T-ALL patients eligible for CART therapy; and ii) reduce the likelihood of immune escape due to the distribution of the immune pressure between the two antigens. We calculate that this OC-1d will extensively widen the inclusion criteria to approx. 80% of all R/R T-ALL patients, representing a unique advancement in the treatment of such an orphan and unmet clinical need.


CAR T CD22 Immunotherapy for B-ALL

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B-ALL is the most common cancer in children and despite current 5-year disease-free survival rates of 80%, relapsed/refractory (r/r) patients still have a dismal outcome. B-ALL is less frequent in adults and still associated with unfavorable clinical outcomes. OC-2 immunotherapy, based on a bispecific CART, is an alternative treatment to salvage chemotherapy followed by autologous stem cell transplantation only suitable for 50% of eligible patients with r/r B-ALL.


Novel γδ T cells allogeneic platform

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Recently, γδ T cells have emerged as an alternative to αβ T cells for cellular immunotherapy. They are not constrained by MHC presentation of tumor‐associated peptides but, providing robust and durable antitumor responses. OneChain platform is a novel and efficient method for a selective, large‐scale generation of human cytotoxic Vδ1+ γδ T cells. They are very attractive candidates for adoptive cell therapy of cancer. Vδ1 naïve cells are produced in a TCR-independent manner and expanded to induce Vδ1+ T cell proliferation, which allows for a significant-fold expansion.


Dual CART against GBM

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Glioblastoma multiforme (GBM) is the most common and most aggressive primary brain tumor in humans, presenting an annual incidence of 3.2 cases per 100,000 individuals (U.S). Patients with GBM have a poor prognosis due to the current limited therapeutic approach, resulting in 5-year survival rates between 6% and 27% (2001-2015). OC-4 is a new immunotherapy against GBM, consisting of a dual CAR-T cell strategy targeting IL13a2/OC-4.2-expressing GBM tumor cells and a key component of the immunosuppressive tumor microenvironment.